"The combination of natural ingredients in ThioZymeGI allows the body’s natural defense mechanisms a chance to re-establish control of the bacterial population in the small intestine."~ Theodore Hersh, M.D.

Understanding Bacteria in the Gut

Intestinal Bacteria: A Natural Occurrence
The entire gastrointestinal tract naturally contains a certain amount of bacteria. The number of bacteria is greatest in the colon (at least 1 billion bacteria per milliliter of fluid), and much lower in the small intestine (less than 10,000 bacteria per ml of fluid)1. The types of bacteria within the small intestine are different than those within the colon1,2.

Bacteria Defense Mechanisms and Overgrowth
The bacterial stability of the small bowel is accomplished by several bodily functions:

  • Stomach acid kills bacteria that are present in foods or drinks.
  • Motility of the small intestine moves bacteria along preventing colonization and avoiding overgrowth.
  • Pancreatic enzymes digest and allow nutrients to be absorbed by the body.
  • Mucosal immune response through IgA secretion constitutes a first line of defense responsible for neutralizing antigens and pathogens.
  • The ileo-cecal valve prevents reflux of colonic contents back into the small intestines.

When one or more of these natural defenses are compromised, bacteria overgrowth in the small intestine can result. The bacteria bind to the lining of the small intestine and mount their own defense mechanism, preventing the body from removing it, causing damage to the digestive tract.

1. Hersh T, et al, Disturbance of the Jejunal and Colonic Bacterial Flora in Immunglobulins Deficiencies, American Journal of Clinical Nutrition, 1970; 23;1595-1601

2. Lee, KJ, et al, Altered Intestinal Microbiota in Irritable Bowel Syndrome, Neurogastroenterology Motility. 2010; 22: 493-498

About ThioZyme GI

including essential oils, chelators and enzymes that can control levels of bacteria in the gut such as E. coli and Bacteroides.
helping establish good bacteria in the gut.
which supports optimal digestive tract function.
GI bottle


These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The information contained in this website is intended for educational purposes only. If you are currently taking medications, or have other health-related conditions, consult a physician before adding supplements to your diet.

The Science

Research has shown that a formula using natural ingredients made up of essential oils, chelators and enzymes can support normal levels of prominent bacteria such as E.coli and Bacteroides species, allowing the body’s natural defense mechanisms to control these bacterial populations in the small intestine. The addition of probiotics to the formula also contributes to maintaining normal populations of bacteria in the small intestine.

In vitro Tests

e coli growth chart

The chart to the left shows an example of one natural ingredient that reduces and one that suppresses bacterial growth, and the combination of the two (the ThioZymeGI formula).




E coli plates
The natural formula changes the E.coli population under physiological conditions.
B sub plates
The natural formula does not interfere with the probiotic B. subtilis population under physiological conditions.


Peer Reviewed Study
A study of the effects of the natural ingredients in ThioZymeGI is published in the Natural Medicine Journal:
Natural Antimicrobial Compounds in Small Intestinal Bacterial Overgrowth Syndrome

Frequently Asked Questions

What is ThioZymeGI?
ThioZymeGI is a formula of natural ingredients including essential oils, chelators and enzymes that helps maintain normal levels of bacteria in the gut, which supports a healthy gut microflora.

How does it work?
ThioZymeGI is built to establish the probiotic B. subtillis in the small intestine, allowing it to flourish and control E. coli and Bacteroides growth by inhibition.

Is it Kosher?
The formula is not Kosher.

Is it Vegetarian or Vegan?
The formula is vegetarian and vegan in accordance with the guidelines of the American Vegetarian Association.

Is it non-GMO?
The microorganisms used to produce this enzyme product are not genetically engineered organisms as defined by the National Organic Standards Board. Genetically engineered is defined as follows:
Made with techniques that alter the molecular or cellular biology of an organism by means that are not possible under natural conditions or processes. Genetic engineering includes recombinant DNA, cell fusion, micro-and macro-encapsulation, gene deletion and doubling, introducing a foreign gene, and changing the position of genes. It shall not include breeding, conjugation, fermentation, hybridization, in-vitro fertilization, and tissue culture.

What is the regulatory status?
All of the individual components of the formula are Generally Recognized As Safe (GRAS).

What is the recommended dosage?
Dosage: 1 Capsule 15 minutes before meals, 2 times daily.

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