Reference Studies
There are numerous studies that demonstrate the safety and efficacy of enzymes and probiotics for use as dietary supplements. Below are just a few of the available reference studies. For more information on additional studies, please contact us.
ENZYMES
Some features of intestinal absorption of intact fibrinolytic enzyme III-1 from Lumbricus rubellus
A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus
Comparative evaluation of alpha-galactosidase A infusions for treatment of Fabry disease
Enzyme replacement therapy in Fabry disease- a randomized controlled trial
Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood
Prevention of murine EAE by oral hydrolytic enzyme treatment
Safety evaluation of a lactase enzyme preparation derived from Kluyveromyces lactis
Safety evaluation of a lipase expressed in Aspergillus oryzae
Safety evaluation of a xylanase expressed in Bacillus subtilis
Safety evaluation of amino peptidase enzyme preparation derived from Aspergillus niger
Safety evaluation of beta-glucanase derived from Trichoderma reesei- summary of toxicological data
Safety evaluation of lipase derived from Rhizopus oryzae- summary of toxicological data
Safety evaluation of lipase G from Penicillium camembertii
Safety evaluation of lipase produced from Candida rugosa- summary of toxicological data
Safety evaluation of lipase produced from Rhizopus oryzae- summary of toxicological data
Systemic enzyme therapy in oncology- effect and mode of action
Transport of proteolytic enzymes across Caco-2 cell monolayers
Trypsin, elastase, plasmin and MMP-9 activity in the serum during the human ageing process
Bromelain
Proteinase activity and stability of natural bromelain preparations
Bromelain treatment decreases neutrophil migration to sites of inflammation
Bromelain modulates T cell and B cell immune responses in vitro and in vivo
In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans
The influence of bromelain on platelet count and platelet activity in vitro
In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain
Use of Bromelain for Mild Ulcerative Colitis
Bromelain in the early phase of healing in acute crush Achilles tendon injury
Protease Supplementation Improves Muscle Function after Eccentric Exercise
Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice
Nattokinase
Anti hypertensive substances in fermented soybean natto
Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of Nattokinase
Fibrinolytic enzymes in Asian traditional fermented foods
Intake of Natto is associated with reduced bone loss in postmenopausal women
Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects
Super Oxide Dismutase (SOD)
Superoxide Radical and Superoxide Dismutases
Topical superoxide dismutase reduces post-irradiation breast cancer fibrosis
Anti-inflammatory activity of various superoxide dismutases on polyarthritis in the Lewis rat
Effect of superoxide dismutase on a rabbit model of chronic allergic asthma
Therapeutic Effect of Lecithinized Superoxide Dismutase on Pulmonary Emphysema
Dietary superoxide dismutase does not affect tissue levels
Superoxide dismutase and catalase as therapeutic agents for human diseases: A critical review
PROBIOTICS
Biotherapeutic effects of probiotic bacteria on candidiasis in immunodeficient mice
Good adhesion properties of probiotics- a potential risk for bacteremia
Lactic acid bacteria inhibit TH2 cytokine production by mononuclear cells from allergic patients
Lactobacilli and bacteremia in southern Finland, 1989-1992
Lactobacillus endocarditis cause by a probiotic organism
Lactobacillus GG effect in increasing IFN-gamma production in infants with cow’s milk allergy
Probiotics- A novel approach in the management of food allergy
Probiotics for treating infectious diarrhoea
Probiotics in Clinical Conditions
Probiotics in prevention of antibiotic associated diarrhoea- meta-analysis
Probiotics in primary prevention of atopic disease- a randomized placebo-controlled trial
Safety of probiotics that contain lactobacilli or bifidobacteria
Small Intestinal Bacterial Overgrowth- Roles of Antibiotics, Prebiotics, and Probiotics
Bacillus subtilis
The Intestinal Life Cycle of Bacillus subtilis and Close Relatives
The Safety of Bacillus subtilis and Bacillus indicus as food probiotics
The Safety of Two Bacillus Probiotic Strains for Human Use
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The information contained in this website is intended for educational purposes only. If you are currently taking medications, or have other health-related conditions, consult a physician before adding supplements to your diet.