Boosting Immunity Through the Gut: How Prebiotics and Probiotics Enhance Overall Well-being

The one health aspect on everyone’s mind right now (and for the foreseeable future) is “immune system.”

Unlike the brain, heart or liver, organs we can identify and generally locate in our bodies, ask someone to point to his or her immune system…you’re likely to get differing opinions or maybe even no response to the question. While immune activity occurs throughout the body, if someone points to his or her gut, this is largely correct. And this is where products (supplements, foods and beverages) formulated for immunity can provide benefit. Immune support products featuring prebiotics and probiotics are the products not only of the future – but of the now.

Research is revealing more clearly the strong relationship between the GI tract and the immune system. The intestines contain more immune cells than the entire rest of the human body. In many cases, immune dysfunction begins with a ‘failure to communicate’ in the human gut. Considering 80 percent of the immune system is in the digestive tract, maintaining a healthy gut is a major focal point in the pursuit to support overall health and immunity.

When the digestive system is functioning properly it serves as a barrier to bacteria, viruses and pathogens. Poor digestion leaves the body and the immune system lacking key components for building blocks, barriers, body defense mechanisms.

How Probiotics Prime the Immune System
Probiotics have been used largely to improve gut health by restoring and maintaining favorable intestinal microbiota. Probiotics support the gut microbiota by producing bacteriocins, facilitating competitive inhibition of pathogenic bacteria, inhibiting bacterial adherence, reducing luminal pH, enhancing the intestinal barrier function by increasing mucus production, producing short chain fatty acids, creating essential amino acids and other nutrients the body needs to function and grow. All these activities result in strengthening immune function.

Probiotics play a crucial role in the development and operation of the mucosal immune system in the digestive tract. When the mucosal membrane lining of the intestines is compromised, immunity is also compromised and there is a greater risk of symptom development.

Bifidobacteria in the intestines are known to provide gut barrier protection. In addition, research has shown that Bifidobacteria help to support the immune system by regulating activity of lymphocytes and phagocytes, which are cells that are essential for fighting infections. Many strains of Lactobacilli have also been shown to support immune function.

Bacillus subtilis has been shown to promote healthy digestion in the intestinal tract, and it also produces various enzymes that facilitate digestion and excretion. It regulates the host’s microbiota and inhibits the growth of pathogenic bacteria. All these activities create an optimal environment for the immune system to function. B. subtilis is a spore-forming probiotic, characterized by its ability to form an endospore (a tough shell) to protect itself from potentially degrading conditions.

The DE111® strain of B. subtilis dually promotes healthy digestive function and immune response by helping resident beneficial bacteria to flourish and multiply, better prohibiting pathogenic or irrelevant bacteria from nestling in. DE111 also primes the immune system, so when foreign invaders enter, the body is able to react faster and stronger to push back and destroy them. Multiple clinical studies support the digestive and immune health benefits of DE111:

  • One study showed that the spore-former generated favorable microbial balance in the gut, supports more effective lower GI digestion and thus supporting overall health.
  • A study in collegiate athletes revealed that after taking DE111® along with post-workout protein supplements for three months, their immune markers were improved and there was a reduction in the pro-inflammatory compound TNF-α.
  • A recently completed study of 93 healthy young children showed that DE111® consumption helped improve immune response. For example, DE111 showed a significant decrease in duration of symptoms associated with illness (cold/flu). Significant differences in the DE111 group included reduced duration of hard stools and vomiting.
  • Preliminary results of a soon-to-be-published study showed that DE111® consumption correlated with a decrease in the basal levels of several immune cell populations, and that the probiotic was able to improve the body’s immune response by eliciting a quicker response to an inflammation stimulus.

Prebiotics
A product addressing immune health can be empowered by the addition of a prebiotic, which supports the proliferation of good bacteria (probiotics) in the gut. Deerland’s innovative prebiotic ingredient is PreforPro®, a unique prebiotic bacteriophage blend that modulates the microbiota and begins to work several hours after ingestion.

PreforPro is a dual-action prebiotic – it destabilizes the cell wall of the undesirable bacteria, which then provides nutrients and space for the good bacteria to grow. PreforPro has been shown to modulate the gut microbiota and encourage the balance of good bacteria over bad. With the unwanted bacteria at a disadvantage, healthy probiotic bacteria have room to take up residence in the gut and flourish. This results in better digestion and improved immune support.

In a clinical study, after 28-days of consuming 15mg of PreforPro daily, researchers found that the phage cocktail positively influenced the gut microbiota, including increased populations of the genera Eubacteria, one of the most abundant in the healthy human gut. Additionally, the researchers saw a reduction in the circulating pro-inflammatory cytokine Il-4.

Launching an Immune Support Supplement Product
At Deerland, our formulation expertise is anchored by the knowledge of how probiotics and prebiotics can work in concert with other functional ingredients.

A sound formulation for a product that supports immune health could include a combination of spore-forming probiotic strains including Bacillus subtilis DE111®, along with additional immunostimulants, vitamins, minerals and antioxidants known for supporting immunity like Vitamin C, Zinc and beta-glucans. Deerland works with customers to develop and launch such products based on the customers target market or specific needs. An additional turnkey product solution is the YourBrand Immuno product line offered by Deerland. These products are available in capsules, fast melt stick packs, mixable powder stick packs and chewable tablets, and are formulated to include Lactobacillus rhamnosus, Bifidobacterium animalis and Vitamin C. Deerland formulates products with ingredients based on studies showing that they can promote healthy immune functions and help support the body’s natural immune system defenses.

After all, the best defense is an optimally functioning defense.

Probiotics and Athletes: New Findings Support Probiotics as Key to Performance and Recovery

Rest, hydration, training, clean eating – these make up much of the traditional core of athletic preparation, and many athletes rely on a regimen chock-full of these solutions to elevate their performance and aid in recovery.

However, according to a new report presented by the International Society for Sports Nutrition (ISSN), they might be missing out on a key ingredient by ignoring the role probiotics can play in their health.

Probiotics offer athletes a wide range of benefits, providing a simple way to improve overall health and prevent common health issues.

Key Findings About Probiotics’ Role in the Health of Athletes

Though the ISSN position paper’s lead author, Dr. Ralf Jaeger, noted that more research is needed regarding the potential of probiotics for athletes, the paper’s findings largely trended toward probiotics playing an impactful and positive role.

Highlights of the team’s findings include:

• Particularly in the case of amino acids from protein, probiotics may increase nutrient absorption in athletes.
• Athletes are at high risk of immune system depression, but specific probiotic strains may help limit and control upper respiratory infections in athletes.
• “Leaky gut” is often a symptom of strenuous exercise, but probiotics can boost gut integrity in athletes.
• Specific, anti-inflammatory strains of probiotics may aid in muscle recovery.

Easing Common Health Concerns in Athletes

The stress athletes place on their bodies makes addressing and treating unique challenges critical, and probiotics can play an important role in that process.

While the ISSN’s findings highlight the ability of probiotics to care for athletes’ immune systems, prevent “leaky gut,” and boost muscle recovery, the benefits don’t stop there.

In addition, probiotics may also promote a more favorable metabolism, help sustain overall health outside of the gut and post-training muscle recovery, improve body composition, and more.

Achieving the Right Balance of Prebiotics and Probiotics

While the benefits of probiotics are clear, achieving a well-balanced gut, particularly in the context of a holistic approach to health, can be challenging.

Striking that balance is critical, as a healthy microbiome supports macronutrient digestion, optimizing nutrient absorption and health benefits.

Fortunately, adding probiotics and prebiotics to athletes’ routines is simpler than ever.

Foods common in athletic diets, like yogurt, fruit, vegetables, oatmeal and more already provide beneficial prebiotics and probiotics, but supplements are evolving every day to become easier to implement in addition to these nutritional choices.

Supplements are showing up in a variety of intake methods, including gummies, mini-drinks and even straws. Products like Deerland’s DE111, a clinically studied strain of Bacillus subtilis, can provide benefits like:

• Control of microbial populations
• Regularity promotion
• Body composition improvement

To learn more about probiotics’ role in a healthier gut, visit https://www.deerland.com/de111/about-probiotics/

How Enzymes And Probiotics Boost Pets’ Digestive Health

You would do anything for your furry friends and their health. They are as much a part of your family as anyone, and you want the best care possible for them.

To that end, enzymes and probiotics are a fantastic way to boost your pets’ overall digestive health, providing numerous benefits and, in some cases, filling in gaps left by your pets’ natural enzyme production.

Learn more below to see just how beneficial Probiotics and Enzymes can be for your four-legged family members.

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Beauty from Within: Antioxidants, Enzymes and Healthy Aging

Beauty from Within Supplement Market Growing, Healthy Aging Is Possible with Solarplast

The desire to look and feel beautiful only continues to grow amongst the population. Through the decades, many have turned to external treatments to help reverse the signs of age; today, however, the demand for ‘beauty from within’ is booming. As such, beauty supplements have risen rapidly in popularity, boasting a market value of over $144 million in the US, according to Euromonitor International.

Why are Healthy Aging and Beauty from Within Supplements on the Rise?

Much of the excitement around this category of supplements is due to an aging population. Per a census report, the percentage of the global population that is 65 or older is estimated to double by 2050. Combine this with a more educated and proactive approach to maturing, and it’s clear to see why these products are in such high demand.

How Do Supplements Impact the Rate of Aging?

Most healthy aging supplements focus on combatting free radicals with antioxidants. Free radicals damage the body’s cells via oxidative stress—a natural process occurring over time that’s influenced by environmental toxins, diet, exercise, and illnesses.

Antioxidants deliver detoxification, slowing the natural process of cell damage. There are many kinds of antioxidants, including vitamins C and E, beta-carotene, and other related carotenoids. The antioxidant with the most potent regeneration capabilities, though, is glutathione.

Offering excellent benefits when paired with enzymes and energy molecules, glutathione is composed of three amino acids—cysteine, glycine, and glutamate. Possessing extremely high glutathione content levels, spinach is a prime dietary and derivation source for the antioxidant. However, while it neutralizes a wide range of oxidants, a glutathione supplement can be difficult for the gut to absorb.


Enter Solarplast®.

So, What is Solarplast?

Deerland—a supplier of science-backed solutions for microbiome health —has harnessed the power of protoplasts found in organic spinach to create Solarplast. Hindering the cell-damaging effects of free radicals, Solarplast is a spinach extract that’s enzymatically enhanced via a proprietary manufacturing process to deliver massive concentrations of detoxifying antioxidants.

The Difference is in the Manufacturing Process

Typical extraction processes destroy the spinach plant’s cell wall as well as the lipid membrane lining the protoplast, exposing the plant’s nutrients and antioxidants to the elements, rendering their benefits unusable. The innovative process to create Solarplast, on the other hand, enables the break-down of the plant’s tough cell wall without immolating the underlying lipid layer. By keeping the naturally occurring lipid coating intact, the spinach cell’s valuable contents are protected.

The Proof is in the Solarplast Pudding

In addition, facilitating the glutathione pathway of antioxidant regeneration, the additional presence of partnering enzymes improve the bioavailability, and thus, the antioxidant power of Solarplast, increasing the absorption of the antioxidants present in spinach by 33%. Demonstrating the ability to persist in cellular repair, in vitro tests with porcine liver exposed to free radical damage have shown that Solarplast yielded a 35% repair to the liver during the first 30 minutes while continuing to repair at more than 60% by 60 minutes. Other antioxidants tested a provided repair after 30 minutes with no further repair at 60 minutes.

Offering all the raw materials needed for the production and regeneration of glutathione, Solarplast ranks at 5 mg per GAE/gram in Total Antioxidant Capacity (TAC), containing more than double the TAC of regular spinach. Solarplast also offers a bounty of other healthy-aging components, including B12, which can improve mental clarity and reduce tiredness after eating, and molecular chaperones that boost the digestive system and provide protection from free radicals.

Deerland: Inner Health for Outer Beauty

Using probiotic, prebiotic and enzyme technology, a team of industry experts and a state-of-the-art lab, Deerland. specializes in developing science-backed solutions that benefit microbiome health. Recognizing a market need for a more comprehensive and effective beauty supplement that protects, repairs and restores, Deerland developed Solarplast—an innovative antioxidant for healthy aging and beauty from within. Learn more about Solarplast today.

Solarplast: Innovative Antioxidant For Healthy Aging and Beauty From Within

Solarplast is an extract of organic spinach which is enzymatically enhanced by a unique and proprietary manufacturing process. It harnesses the power of the protoplasts found in spinach to provide a rich source of antioxidants and their enzyme partners, all in a naturally occurring lipid protective coating. Solarplast provides a host of benefits for healthy aging, optimizing the body’s processes through cellular restoration and repair.

Learn how the enzyme-powered antioxidant promotes healthy aging and beauty from within.

PreforPro: What It Is And How It Works

PreforPro is a next-generation prebiotic that supports the growth of healthy bacteria in the gut utilizing phage technology. But how exactly does PreforPro work? Learn more below.

Creating a Unique Dietary Supplement Formulation

In pace with the ongoing escalation in health-related research and scientific advancements, consumers are becoming increasingly mindful of their health, translating to a surge in preventative and preservative well-being habits. As such, supplements are playing a common and vital role in the daily routines of the health-conscious consumer. However, with such a wide variety of lifestyles to cater to, the one-size-fits-all approach no longer suffices. Thus, manufacturers are now developing tailored experiences to accommodate the targeted results of the individual, providing personalized nutrition with customization fueling innovation.

Consumer-Driven

Today’s consumers are making better health-conscious decisions and gaining better control of their well-being by educating themselves on ailments and ways to improve them. With countless magazine articles, television series, online forums and research studies lauding the benefits of preventative healthcare, an influx of readily available health-related information is boosting consumer awareness and driving the market demand for health-enhancing supplements. Further, with the rise in insurance plan and co-pay costs, there is an increased reliance on these alternative channels as a medium that can help them identify and self-diagnose their individual health needs. In fact, when seeking health information, 80% of the American population uses the internet throughout all parts of their health journey. Market growth, along with this upsurge in self-directed behavior, has resulted in manufacturers and retailers seeking innovative ways to create a personalized regimen tailored to specific consumers.

Custom Formulation

While younger generations have shown to be more proactive with their health than previous generations, incorporating more health-promoting habits in their day-to-day lives, personalized nutrition has become a key consumer focus in all demographics. However, to gain more control over their health and well-being, today’s consumers are seeking to target specific health concerns with customized supplement formulations. Additionally, many consumers would prefer an alternative to taking supplements in pill form or taking multiple pills for various needs. As demand continues to shift away from the all-inclusive approach, manufacturers are creating supplementary structures, foods, and beverages to meet the highly focused needs of the modern consumer.

Custom Focus

Whether manufacturers choose to focus on a particular area of science or a specific area of the body, the opportunity for customization is endless. With a greater understanding of how genetic differences impact the way supplements are absorbed, metabolized and utilized by each individual, personalized supplement strategies are the new way for consumers to optimize health and performance based on their genetic profile and specific preferences. As consumers continue to search for niche solutions—from increased athletic performance to child-safe formulations—manufacturers are implementing an exceedingly directed approach to supplement development.

Specified Benefits

When searching for new supplements, consumers want what is best for them, not everyone else. As such, many people are taking DNA tests to learn more about their body and particular needs. As this trend continues to progress, consumers will seek more products with specified benefits and targeted results. For example, as food sensitivities become more common, people are paying closer attention to the way their body responds to what they intake. With many food sensitivities caused by a lack of necessary enzymes to help break down food, consumers are turning to enzymes in supplement form to improve gut health. However, certain enzymes have also been shown to help with muscle recovery, tissue repair and reduce inflammation, dental and sinus complaints as well. From new research to greater health consciousness, to specified needs, supplements are growing in type, application, and formulation. Thus, a dietary supplement formulation that targets the consumer’s individual needs is essential.

Deerland Probiotics & Enzymes specializes in developing customized science-backed solutions that benefit microbiome health, using probiotic, prebiotic, and enzyme technology. Our YourBlend online tool helps formulators start building a supplement geared toward specific performance benefits. Don’t know where to start? Contact us, and our product development experts will guide you through the process, from concept to commercialization.

Are Supplements “One Size Fits All?”

A survey commissioned by the Council for Responsible Nutrition found that 75% of adults use dietary supplements, which is 10% more than a decade ago. Obviously, each consumer has their own needs, and there is no “one size fits all” solution. That’s why the industry is evolving toward greater customization, driven by the needs and wants of each generation, from Baby Boomers to Gen Xers to Millennials.

Shifting Definitions of Sustainability

Trends continually change, and each generation adheres to its unique values, which impacts preferences in diet, social and environmental issues, and sustainability. Most businesses have embraced what is called the three dimensions of sustainability, sometimes called “the three E’s” for economy, equity, and ecology. This model assumes that for a company to be sustainable, it must be economically feasible, environmentally dependable, and socially responsible. In contrast, the general population associates other concepts with sustainability, such as social justice, local farming, and organic food production. Nonetheless, sustainability is really the description of a successful attempt to keep the world’s population fed. This goal depends on the availability of fertile land, water, nutrients, and an adequate climate.

Clean and Green Millennials

There is a growth in clean eating, driven by Millennials. Emotionally engaged in their physical health, this generation has a more holistic outlook, meaning that they monitor their energy levels, digestion, and overall feeling of well-being to measure their health.

Three Generations: The Triple Threat       

The needs of aging Baby Boomers have a tremendous impact on the supplement landscape, and are vital drivers in condition-specific supplement formulas. Millennials, however, tend to focus on personalization and customization, and will likely have the greatest influence on the forward movement of functional foods. In essence, Boomers generate the volume, but Millennials and Gen Z hold the future in their hands.

Age and Social Preference Predict Supplement Needs

With three-quarters of Americans using dietary supplements, a steady increase in use has been observed, indicating a shift toward a more holistic and personalized approach to health. Social preferences, age, and health are all critical indicators of the supplement space. While we know that adults 55 and over make up the volume of the current market, as might be expected, their supplement choices look quite different from that of the Gen Xers that follow them.

While we all have digestive issues that are a nuisance form time to time, the aging digestive system undergoes some serious changes. Inadequate diet and an unhealthy microbiome lays the groundwork for weak digestion and reduced nutrient absorption. What might be surprising though is that Millennials are using probiotics more than the predecesors, Gen X and Baby Boomers. The digestive systems of 20-somethings are probably in great shape, but one of the differentiators of this demographic is that they are concerned with wellness, including fresh and healthy foods. Consumers in their 50’s and 60’s may turn to probiotics out of necessity, but 18-35 year-olds aim to boost their overall health.

Deerland Customizes and Individualizes

Deerland Probiotics & Enzymes is a leading specialty formulator and contract manufacturer of enzyme- and probiotic-based dietary supplements. With a team of industry experts working in a state-of-the-art lab, we’re positioned to serve customers from the initial stages of product conceptualization, through the design phase, final formulation, and contract manufacturing. From concept to commercialization, we add value at every step. Learn more at Deerland.com.

Probiotics: Evolving Function, Microbiome Masters & Athletic Performance

While probiotics are primarily associated with digestive and gut health, they are the masters of the microbiome, which is a crucial factor when it comes to sustaining overall health. With an increase in consumer interest, probiotics continue to evolve through delivery formats, strain diversity, and manufacturing processes. These advancements provide new functional foods, beverages, gummies, and more while granting benefits that can improve health and increase performance abilities.

Probiotics: Masters of the Entire Microbiome

The microbiome consists of trillions of microorganisms from thousands of species, including bacteria, fungi, parasites, and viruses. With 70% of the body’s immune cells located in the digestive tract, probiotics are vital, helping the microbiome create and maintain balance. Within the microbiome of a healthy person, these microorganisms coexist peacefully, with most residing in the small and large intestines, but also throughout the body. Because the microbiome consists of microorganisms that are both helpful and potentially harmful, it’s essential to avoid dysbiosis.

Probiotics are Continually Evolving

Probiotics continue to evolve as consumer interest drives demand. As a result, researchers are discovering new health benefits of probiotic strains, and manufacturers are improving technologies and techniques. Probiotic strains vary in their unique benefits and characteristics that influence suitability and application, such as skin, health, or mood support. Lactobacillus and bifidobacterium have been the most common strains used in dietary supplements, but new interests include synbiotics, immunobiotics, psychobiotics, and postbiotics.

 Not Just a Pill

The increase in probiotic demand has also led manufacturers to move beyond capsules and become more innovative in the delivery of their products. With a never-ending search for the most convenient products, pill alternatives are on the rise. For example, children can ingest a daily probiotic that is in the form of a straw, alleviating the struggle of swallowing a pill. Functional foods and beverages, such as gummies and mini-drinks, are a more enticing delivery method, and for some, a more accessible option.

 Benefits Athletic Performance

A well-balanced gut flora provides many benefits, including smooth digestion, protection against pathogens, vitamin and nutrient absorption, and immune support. These functions are critical for fitness enthusiasts and athletes—essential to improving performance—and the high nutrient needs of these active individuals are best met via healthy digestion. A healthy microbiome supports the digestion of macronutrients, allowing for optimized nutrient absorption. Probiotics can also aid muscle growth, recovery time, and reduced inflammation by promoting the absorption of key amino acids. The strain Bacillus subtilis DE111® (from Deerland) produces many enzymes to help break down protein, and recent research supported its role in reducing markers of inflammatory compounds that arise during exercise. As more clinical data is collected, the role of probiotics in athletes becomes an important link for improved performance.

Deerland Probiotics & Enzymes developed DE111, a genome sequenced and clinically tested strain of Bacillus subtilis––a probiotic spore that supports digestive and immune health. Human clinical studies show the strain’s ability to control microbial populations, aid in digestion, and maintain general health. DE111 has the ability to form spores that protect the microbes from harsh conditions until they enter an environment ripe for germination, such as the GI tract. Because of this spore-forming ability, DE111 remains viable under a wide temperature and pH range, making it ideal for use in supplements as well as food and beverages. Besides DE111, Deerland has developed an exclusive line of university-studied products which can be used as-is, or as the basis for a custom formulation. To learn more about Deerland and DE111, click here.

From Chocolate to Kimchi: Probiotic Foods of Today

The benefits and impact of probiotic-rich foods have been appreciated for centuries. From staples like yogurt, sauerkraut and tempeh, to kimchi and kefir – probiotics are found in foods around the world. As the importance of gut health is better understood, foods and beverages are being enhanced with probiotics. These are known as functional foods, and they exist to improve health and digestion. Watch below to learn more!

For more information on DE 111 and it’s possibilities for digestive and immune health, click here.

The 4 P’s: Plant-based, Protein, Probiotics, and Prebiotics

As vegetarianism and veganism continue to grow in popularity, the term “plant-based” appearing on more and more food, beverage and supplement products. According to Mintel, the number of new food and drink products in the United States that are labeled as “plant-based” grew 268 percent from 2012 and 2018. So what does this plant-powered revolution mean in the world of the other three P’s – probiotics, prebiotics and protein?

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What is the Microbiome?

The ability to understand the microbiome and its impact on the body is continually growing with advances in sequencing methods and initiatives like the Human Microbiome Project. But what exactly is the microbiome? Learn more below.

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