PreforPro: What It Is And How It Works

PreforPro is a next-generation prebiotic that supports the growth of healthy bacteria in the gut utilizing phage technology. But how exactly does PreforPro work? Learn more below.

Creating a Unique Dietary Supplement Formulation

In pace with the ongoing escalation in health-related research and scientific advancements, consumers are becoming increasingly mindful of their health, translating to a surge in preventative and preservative well-being habits. As such, supplements are playing a common and vital role in the daily routines of the health-conscious consumer. However, with such a wide variety of lifestyles to cater to, the one-size-fits-all approach no longer suffices. Thus, manufacturers are now developing tailored experiences to accommodate the targeted results of the individual, providing personalized nutrition with customization fueling innovation.

Consumer-Driven

Today’s consumers are making better health-conscious decisions and gaining better control of their well-being by educating themselves on ailments and ways to improve them. With countless magazine articles, television series, online forums and research studies lauding the benefits of preventative healthcare, an influx of readily available health-related information is boosting consumer awareness and driving the market demand for health-enhancing supplements. Further, with the rise in insurance plan and co-pay costs, there is an increased reliance on these alternative channels as a medium that can help them identify and self-diagnose their individual health needs. In fact, when seeking health information, 80% of the American population uses the internet throughout all parts of their health journey. Market growth, along with this upsurge in self-directed behavior, has resulted in manufacturers and retailers seeking innovative ways to create a personalized regimen tailored to specific consumers.

Custom Formulation

While younger generations have shown to be more proactive with their health than previous generations, incorporating more health-promoting habits in their day-to-day lives, personalized nutrition has become a key consumer focus in all demographics. However, to gain more control over their health and well-being, today’s consumers are seeking to target specific health concerns with customized supplement formulations. Additionally, many consumers would prefer an alternative to taking supplements in pill form or taking multiple pills for various needs. As demand continues to shift away from the all-inclusive approach, manufacturers are creating supplementary structures, foods, and beverages to meet the highly focused needs of the modern consumer.

Custom Focus

Whether manufacturers choose to focus on a particular area of science or a specific area of the body, the opportunity for customization is endless. With a greater understanding of how genetic differences impact the way supplements are absorbed, metabolized and utilized by each individual, personalized supplement strategies are the new way for consumers to optimize health and performance based on their genetic profile and specific preferences. As consumers continue to search for niche solutions—from increased athletic performance to child-safe formulations—manufacturers are implementing an exceedingly directed approach to supplement development.

Specified Benefits

When searching for new supplements, consumers want what is best for them, not everyone else. As such, many people are taking DNA tests to learn more about their body and particular needs. As this trend continues to progress, consumers will seek more products with specified benefits and targeted results. For example, as food sensitivities become more common, people are paying closer attention to the way their body responds to what they intake. With many food sensitivities caused by a lack of necessary enzymes to help break down food, consumers are turning to enzymes in supplement form to improve gut health. However, certain enzymes have also been shown to help with muscle recovery, tissue repair and reduce inflammation, dental and sinus complaints as well. From new research to greater health consciousness, to specified needs, supplements are growing in type, application, and formulation. Thus, a dietary supplement formulation that targets the consumer’s individual needs is essential.

Deerland Probiotics & Enzymes specializes in developing customized science-backed solutions that benefit microbiome health, using probiotic, prebiotic, and enzyme technology. Our YourBlend online tool helps formulators start building a supplement geared toward specific performance benefits. Don’t know where to start? Contact us, and our product development experts will guide you through the process, from concept to commercialization.

Are Supplements “One Size Fits All?”

A survey commissioned by the Council for Responsible Nutrition found that 75% of adults use dietary supplements, which is 10% more than a decade ago. Obviously, each consumer has their own needs, and there is no “one size fits all” solution. That’s why the industry is evolving toward greater customization, driven by the needs and wants of each generation, from Baby Boomers to Gen Xers to Millennials.

Shifting Definitions of Sustainability

Trends continually change, and each generation adheres to its unique values, which impacts preferences in diet, social and environmental issues, and sustainability. Most businesses have embraced what is called the three dimensions of sustainability, sometimes called “the three E’s” for economy, equity, and ecology. This model assumes that for a company to be sustainable, it must be economically feasible, environmentally dependable, and socially responsible. In contrast, the general population associates other concepts with sustainability, such as social justice, local farming, and organic food production. Nonetheless, sustainability is really the description of a successful attempt to keep the world’s population fed. This goal depends on the availability of fertile land, water, nutrients, and an adequate climate.

Clean and Green Millennials

There is a growth in clean eating, driven by Millennials. Emotionally engaged in their physical health, this generation has a more holistic outlook, meaning that they monitor their energy levels, digestion, and overall feeling of well-being to measure their health.

Three Generations: The Triple Threat       

The needs of aging Baby Boomers have a tremendous impact on the supplement landscape, and are vital drivers in condition-specific supplement formulas. Millennials, however, tend to focus on personalization and customization, and will likely have the greatest influence on the forward movement of functional foods. In essence, Boomers generate the volume, but Millennials and Gen Z hold the future in their hands.

Age and Social Preference Predict Supplement Needs

With three-quarters of Americans using dietary supplements, a steady increase in use has been observed, indicating a shift toward a more holistic and personalized approach to health. Social preferences, age, and health are all critical indicators of the supplement space. While we know that adults 55 and over make up the volume of the current market, as might be expected, their supplement choices look quite different from that of the Gen Xers that follow them.

While we all have digestive issues that are a nuisance form time to time, the aging digestive system undergoes some serious changes. Inadequate diet and an unhealthy microbiome lays the groundwork for weak digestion and reduced nutrient absorption. What might be surprising though is that Millennials are using probiotics more than the predecesors, Gen X and Baby Boomers. The digestive systems of 20-somethings are probably in great shape, but one of the differentiators of this demographic is that they are concerned with wellness, including fresh and healthy foods. Consumers in their 50’s and 60’s may turn to probiotics out of necessity, but 18-35 year-olds aim to boost their overall health.

Deerland Customizes and Individualizes

Deerland Probiotics & Enzymes is a leading specialty formulator and contract manufacturer of enzyme- and probiotic-based dietary supplements. With a team of industry experts working in a state-of-the-art lab, we’re positioned to serve customers from the initial stages of product conceptualization, through the design phase, final formulation, and contract manufacturing. From concept to commercialization, we add value at every step. Learn more at Deerland.com.

Probiotics: Evolving Function, Microbiome Masters & Athletic Performance

While probiotics are primarily associated with digestive and gut health, they are the masters of the microbiome, which is a crucial factor when it comes to sustaining overall health. With an increase in consumer interest, probiotics continue to evolve through delivery formats, strain diversity, and manufacturing processes. These advancements provide new functional foods, beverages, gummies, and more while granting benefits that can improve health and increase performance abilities.

Probiotics: Masters of the Entire Microbiome

The microbiome consists of trillions of microorganisms from thousands of species, including bacteria, fungi, parasites, and viruses. With 70% of the body’s immune cells located in the digestive tract, probiotics are vital, helping the microbiome create and maintain balance. Within the microbiome of a healthy person, these microorganisms coexist peacefully, with most residing in the small and large intestines, but also throughout the body. Because the microbiome consists of microorganisms that are both helpful and potentially harmful, it’s essential to avoid dysbiosis.

Probiotics are Continually Evolving

Probiotics continue to evolve as consumer interest drives demand. As a result, researchers are discovering new health benefits of probiotic strains, and manufacturers are improving technologies and techniques. Probiotic strains vary in their unique benefits and characteristics that influence suitability and application, such as skin, health, or mood support. Lactobacillus and bifidobacterium have been the most common strains used in dietary supplements, but new interests include synbiotics, immunobiotics, psychobiotics, and postbiotics.

 Not Just a Pill

The increase in probiotic demand has also led manufacturers to move beyond capsules and become more innovative in the delivery of their products. With a never-ending search for the most convenient products, pill alternatives are on the rise. For example, children can ingest a daily probiotic that is in the form of a straw, alleviating the struggle of swallowing a pill. Functional foods and beverages, such as gummies and mini-drinks, are a more enticing delivery method, and for some, a more accessible option.

 Benefits Athletic Performance

A well-balanced gut flora provides many benefits, including smooth digestion, protection against pathogens, vitamin and nutrient absorption, and immune support. These functions are critical for fitness enthusiasts and athletes—essential to improving performance—and the high nutrient needs of these active individuals are best met via healthy digestion. A healthy microbiome supports the digestion of macronutrients, allowing for optimized nutrient absorption. Probiotics can also aid muscle growth, recovery time, and reduced inflammation by promoting the absorption of key amino acids. The strain Bacillus subtilis DE111® (from Deerland) produces many enzymes to help break down protein, and recent research supported its role in reducing markers of inflammatory compounds that arise during exercise. As more clinical data is collected, the role of probiotics in athletes becomes an important link for improved performance.

Deerland Probiotics & Enzymes developed DE111, a genome sequenced and clinically tested strain of Bacillus subtilis––a probiotic spore that supports digestive and immune health. Human clinical studies show the strain’s ability to control microbial populations, aid in digestion, and maintain general health. DE111 has the ability to form spores that protect the microbes from harsh conditions until they enter an environment ripe for germination, such as the GI tract. Because of this spore-forming ability, DE111 remains viable under a wide temperature and pH range, making it ideal for use in supplements as well as food and beverages. Besides DE111, Deerland has developed an exclusive line of university-studied products which can be used as-is, or as the basis for a custom formulation. To learn more about Deerland and DE111, click here.

From Chocolate to Kimchi: Probiotic Foods of Today

The benefits and impact of probiotic-rich foods have been appreciated for centuries. From staples like yogurt, sauerkraut and tempeh, to kimchi and kefir – probiotics are found in foods around the world. As the importance of gut health is better understood, foods and beverages are being enhanced with probiotics. These are known as functional foods, and they exist to improve health and digestion. Watch below to learn more!

For more information on DE 111 and it’s possibilities for digestive and immune health, click here.

What is the Microbiome?

The ability to understand the microbiome and its impact on the body is continually growing with advances in sequencing methods and initiatives like the Human Microbiome Project. But what exactly is the microbiome? Learn more below.

CLICK IMAGE TO EXPAND

Click here to download.

Prebiotic PreforPro® Shown to Positively Impact Gut Microbiota, According To Clinical Study

A newly published human clinical study demonstrates the efficacy of the bacteriophage (phage) cocktail PreforPro® in favorably supporting the gut microbiota and systemic markers. PreforPro is patented for use as a prebiotic.

The study, PHAGE Study: Effects of Supplemental Bacteriophage Intake on Inflammation and Gut Microbiota in Healthy Adults published in Nutrients, is a randomized, double-blind, placebo-controlled crossover intervention trial involving 43 participants aged 18 to 65.

According to the researchers, the goal was to determine how daily consumption of supplemental phages (PreforPro®), influences the gut microbiota of healthy adults with self-reported gastrointestinal distress. In addition, the team sought to determine effects of phage ingestion on microbial production of short chain fatty acids (SCFAs) as well as if phages alter both lipid metabolism and markers of local and systemic inflammation.

The team found that 28-days of PreforPro consumption favorably modified several bacterial species, including increased populations of the genera Eubacterium, one of the most abundant genera in the healthy human gut. Additionally, the researchers saw a reduction in the circulating pro-inflammatory cytokine Il-4, which is correlated with autoimmune and allergic responses. According to the authors of the study, these data highlight the potential of bacteriophages for selective modification of targeted microbial species without inducing dysbiosis.

In conclusion, according to the authors, “bacteriophage consumption caused minimal disruption to the gut microbiota but did elicit minor changes which may be viewed as beneficial overall…and increases in fermentative taxa capable of butyrate production suggest a shift towards a healthier gut environment.”

This human clinical study on PreforPro further validates observations in prior in vitro and mouse studies, which showed enhanced growth of a broad spectrum of probiotic species including B. breve, L. acidophilus, L. paracasei, L. casei, L. rhamnosus, Lc. Lactis and B. subtilis. Further, these effects were seen after only five hours after PreforPro administration.

“Ingesting probiotics are only half the healthy gut microbiome equation; effective prebiotics are the other half that encourage resident beneficial bacteria to populate,” says John Deaton, vice president of science & technology for Deerland Probiotics and Enzymes. PreforPro is unique in that it is a bacteriophage that is patented for use as a prebiotic, and it’s attractive for consumers who are concerned about starch consumption and having to take large doses – as PreforPro is a non-starch/fiber compound that exerts its prebiotic abilities in a small, 15mg dose.”

Stick Packs Provide Consumers with a Convenient Packaging Option for Supplements

Delivering supplements in standard plastic bottles is a time-tested and familiar way for manufacturers to supply products to consumers. But with so many options and brands available today, it’s important to look for ways to differentiate a brand and stand out from the crowd. Alternative packaging is one way to differentiate products on retail shelves, and stick packs are one of the most exciting new options available.

Stick Packs are Perfect for Consumers On-the-Go

Stick packs are available in a wide variety of sizes and configurations. Generally, they take the form of a small pouch, packet, or tube made from a flexible film, so they are easily opened, portable, and can be consumed virtually anywhere. The product is typically prepared for direct consumption and provides the complete recommended dose in a single serving. Stick packs are available for powdered products, and sometimes even those in liquid form. A sports drink powder, for example, may be more desirable in a stick pack rather than in a jar or bottle because customers can take the product with them and easily mix and consume it exactly when and where they need it. Best of all, with stick packs, a single product can be delivered in an assortment of flavors rather than just one, offering consumers choice and variety.

Stick Pack are also Good for the Environment

Consumers’ desire for ease-of-use is driving a number of trends including single-use products, on-the-go consumables, and blister packs for pills and capsules. Stick packs address each of these needs. However, as society becomes more concerned with environmental and sustainability issues, brand owners are trying to reduce their carbon footprint. Packaging companies are facilitating eco-friendly processes through the use of responsible materials, recycled or recyclable products, switching from one standard pack-type to another with an improved footprint, trimming waste and reducing package weight. Stick packs improve sustainability since they typically use less material than the majority of single-serve or convenience packaging.

Partnering with the Right Packaging Manufacturer is Essential

Many brand owners are attempting to lessen their manufacturing impact on the environment by outsourcing packaging, but it is essential to partner with an experienced firm. Because most powders will begin reacting as soon as they come into contact with moisture, it is essential to package and seal the product in a controlled production environment.

Deerland Probiotics & Enzymes delivers contract manufacturing services for science-backed enzyme and probiotic-based formulations. As a start-to-finish provider, we offer stick packs, as well as encapsulation, tableting, coatings, bulk powder, labeling and bottling in a safe and sanitary environment. To learn more about our production and packaging capabilities, visit https://www.deerland.com/services/production/.

Digestion and PreforPro: Lori’s Story

Digestive issues are not an anomaly. On an average day 70,000,000 people experience some type of digestive issue. You might be one of them.

There are many factors that impact digestive health and overall health. Your gut hosts an entire ecosystem of bacteria that help with digestion. Good bacteria, and bad. It’s important to have a a balanced microbiome, as it helps facilitate digestion and provides the vitamins and nutrients for a viable immune system.

But often diet alone is not enough. What you feed your body can have a great impact on your gut and digestion, and prebiotics have the potential to help.

Prebiotics support the growth of beneficial probiotic bacteria that promote a healthy digestive tract. Watch Lori’s story below to learn how a prebiotic, PreforPro, helped regulate her digestive problems.

PreforPro is a novel prebiotic that helps restore microbiome balance by crowding out bad bacteria, so good bacteria have room to grow. It aids in your digestion and helps maintain overall health. Working in both the large and small intestine, it’s clinically proven to influence the microbial population of the gut, yielding benefits for systemic health. Discover a better prebiotic with PreforPro today.

How Gut Health Impacts Whole Body Health

Did you know that your gut health is connected to many aspects of your overall health? It’s a very complex part of the body with 100 trillion bacteria—more than in any other part of the body. This group of bacteria is known as the gut microbiota, and they have become a particular focus for researchers who are aiming to learn exactly how this system influences and even improves health.

Gut Microbiota is Unique for Every Individual

About 1,000 different species exist in those trillions of bacteria, representing around 5,000 specific strains. With so many kinds of bacteria, all guts are unique, but certain combinations have been found in the healthiest individuals. There are a variety of factors that impact a gut, including age, diet, genes, the environment, and medications.

What Gut Microbiota Does

Gut microbiota has several different roles in the body. It metabolizes nutrients from the food you eat and the medications you take. It also serves as a barrier against intestinal infections, and produces vitamin K, which is a building block of blood-clotting proteins. These factors are now known, but gut microbiota may do even more. Research, mostly involving animals, suggests it could be associated with overall health. The challenge is determining which actual species or strains have these unique properties.

Latest Findings Signify Microbiota is the Most Important Part of the Gastrointestinal System

New developments have been made in the study of microbiota. Two studies from the Mayo Clinic infer gut bacteria could predict if a person is more susceptible to rheumatoid arthritis (RA). Additionally, it could be a means to determine the best treatment for the condition. Researcher Veena Taneja, Ph.D. published two studies related to the subject in Genome Medicine and Arthritis and Rheumatology. The Genome Medicine published study reports that researchers were able to isolate specific bacteria that that had high populations in RA patients, while finding they were low in healthy individuals.

Cardiovascular and heart health are additional body systems connected to gut health. A study published in the Journal of Applied Microbiology links gut microbiota and gut permeability to the vascular system. In experimentation with mice, reduced levels of A muciniphila increased the likelihood of arterial plaque buildup. The findings also suggested that dietary prebiotics could increase the abundance of A muciniphila, thus decreasing plaque buildup and the resulting inflammation.

Microbiota Communicates with the Immune System

Another positive impact of balanced gut health is how the microbiota communicates with the immune system. There have already been discoveries about the relationship, and they are laying the foundation for possible future applications. More trials of probiotics and prebiotics is necessary to reach this possibility.

Probiotics Encourage Good Gut Health

The gut flora is important to a variety of the body’s functions with 70% of the immune cells located in the digestive tract. This means that gut health is essential to overall health. A healthy, well-balanced gut flora helps with digestion, protects from pathogens, delivers vitamins and nutrients, and is part of the immune system. To reap the benefits of good gut health, probiotics are vital.

Probiotics are those bacteria referred to as “good” or “beneficial.” Probiotic bacteria may be consumed in foods or supplements. When consumed through food or supplements, probiotics are able to thrive in the intestinal environment and provide benefits that aid in digestion and support normal bowel function. Learn more about probiotics and how they impact gut health by checking out this Probiotics 101.