Digestible Podcast: The Future Of Microbiome Product Development

The market of products containing probiotic and prebiotic supplements is unlike any time in history.

No longer confined to a pill or yogurt, there is a wide swath of products available for consumers concerned about their gut health. Noah Voreades, managing director for GenBiome Consulting, says products like Olipop soda or probiotic gummies on the market not only are expanding the demographics of those using products to help gut health but also changing ideas of probiotics across generations.

“I think a perfect example is college students, which can fall anywhere from the older edge of Gen Z to younger millennials, they buy products now that they’re home during COVID, having to educate themselves remotely. They’re having interactions with their parents, their parents are seeing them consuming new and novel products that they find really efficacious that taste good, that meet their lifestyle and there’s this cross-mingling.”

That sort of experience can encourage members of the baby boomer generation, who my be fatigued by taking a number of pills, to utilize microbiome-based products in a non-traditional form.

Beyond simply taking age and taste into consideration, the microbiome market is drilling down even more on the individual.

“The reason why personalization is entering the microbiome product space is because consumers, we’re becoming used to things being designed, built experienced around us,” said Voreades, citing algorithms used by Netflix or Spotify. “That’s bleeding into the drive to make microbiome products more personalized. Also, I think foundationally when we look at the science and the state of the science in the microbiome space, we’re starting to realize that everyone’s microbiome is very unique. There’s a lot of variation between you and I.”

The advances in technology will be fascinating to follow as science continues to dedicate serious resources to exploring gut health and how it can be improved across age groups and other demographic groups.

New Study: Probiotic DE111® Found to Support Cardiovascular Health

Deerland Probiotics and Enzymes has announced the publication of a clinical study demonstrating efficacy of the probiotic Bacillus subtilis DE111® in promoting healthy endothelial function and support of healthy cholesterol levels.

The study, “Bacillus subtilis DE111 intake may improve blood lipids and endothelial function in healthy adults” published in Beneficial Microbes, was performed at a leading university specializing in probiotics research and is an IRB-approved, randomized, double-blind, placebo-controlled four-week trial involving 43 participants aged 18 to 65.

The overall goal of this parallel arm trial was to determine if various cardiovascular parameters in healthy adults could be altered by probiotic supplementation. This new research was based on findings from previous studies that showed clear correlations between certain probiotic strains and healthy vascular function, reduced systemic inflammation and glucose tolerance, as well as evidence that the species Bacillus subtilis can support healthy cholesterol levels with positive cardiovascular effects in animal models.

The research team found that B. subtilis DE111 supplementation of 1 billion CFU per day resulted in significant reduction in total cholesterol and non-HDL cholesterol relative to baseline measures. The team also observed a strong trend toward reduction in LDL cholesterol, as well as improvement in endothelial function; reactive hyperemia index (RHI), an indicator of blood flow and heart health, increased by 9.14%.

“To our knowledge, this is the first randomized controlled trial to investigate the effects of B. subtilis supplementation on these parameters in a human population,” the principal investigators of the study stated. The authors of the study believe that B. subtilis supplementation may have an indirect effect on enhancing the generation of short chain fatty acids (SCFA) leading to this cholesterol lowering effect.

“Notably, these effects were observed in a population of healthy individuals, and the results strongly suggest that B. subtilis supplementation may help support cardiovascular health,” commented Dr. John Deaton, vice president of science and technology at Deerland.

Deaton added that the spore-forming properties of the probiotic DE111® allow formulating in a wide array of attractive consumer products even beyond traditional supplement capsules, including gummies, chocolates, functional beverages and fitness nutrition powders.

The Growth of Synbiotics and Their Impact on the Probiotics Market

There’s a “new” hot topic in gut health. While the concept of “synbiotics” was first proposed more than two decades ago, the term is coming back into the collective supplement lexicon in a big way.

So, what are synbiotics, and what impact will they have on the probiotics market and the way consumers use and view supplements?

Defining Synbiotics

Probiotics are live, beneficial bacteria that help contribute to a healthy gut, while prebiotics are indigestible substrates that help “good” bacteria grow and thrive. Synbiotics, then, refer to the practice of combining the two into a single promoter of good digestive health.

However, this definition could also be limiting. Instead, a panel of experts labeled synbiotics “a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host.”

Essentially, synbiotics are a combination of “good” bacteria and the things that help keep those bacteria alive, with the end goal of delivering health benefits to consumers.

Synbiotics and Their Market Share Are Growing

While probiotics have traditionally dominated microbiome support sales, prebiotics and synbiotics are gaining ground.

In particular, synbiotics are expected to continue eclipsing $2.5 billion in sales each year through 2023, according to Nutrition Business Journal, and the overall growth percentage of both prebiotics and synbiotics will continue to outpace probiotics.

This growth could come from a variety of consumer motivations, including better education and a desire for more sophisticated gut-health solutions. According to a New Hope Network NEXT Data and Insights survey, consumers are increasingly concerned with immunity, which now lands alongside general health and wellness and vitamin intake as key drivers for supplement use.

In short, consumers are looking for supplements that deliver wholistic health benefits, and with results backed by science and measurable impact.

How PreforPro® Delivers Synbiotic Benefits

Deerland’s novel prebiotic PreforPro®, a blend of bacteriophages, exhibits synbiotic benefits when combined with probiotic supplementation, suggesting synergistic benefits for users.

In fact, a study designed to test PreforPro’s efficacy in delivering these synbiotic benefits “observed improvements in GI inflammation and a trending improvement in colon pain  in individuals consuming B. lactis with PreforPro, but not in the group consuming only the probiotic.” In addition, a significant increase in Lactobacillus species was observed, demonstrating that supplementing the probiotic B. lactis with PreforPro can significantly modulate gut ecology to favor beneficial bacteria.

This means that PreforPro® proved more effective than a probiotic alone, suggesting that “the addition of PreforPro® as a combination therapy may alter gut ecology to extend the GI benefits of consuming B. lactis or other probiotics.”

To learn more about PreforPro® and Deerland’s other solutions for microbiome health, contact us today.

Condition-Specific Probiotics for Sleep, Mood and the Immune System

Probiotics are known as “good” or “beneficial” bacteria. Probiotic supplements and foods rich in them can deliver many benefits for the human body. Dozens of different probiotic bacteria contribute to improved health.

Most people are aware of how they help the digestive system, but probiotics impact other aspects of health, as well. With this in mind, the product development specialists at Deerland stand ready to provide turnkey product formulations solutions, as well as help with developing customized, condition-specific formulas with a probiotic base. Let’s look at the benefits of probiotics for sleep, mood and the immune system.

Probiotics and Better Sleep

Everyone wants more restorative sleep. According to the American Sleep Association (ASA), 50 to 70 million adults have a sleep disorder. Insomnia is the most common.

Because of the prevalence of inadequate sleep, many seek treatments, including taking supplements. A specially formulated probiotic for rest could provide relief. An example sleep support with probiotics formula may include:

  • Probiotic Bacillus subtilisDE111®: It aids in keeping intestines healthy and digestion normal. If the digestive system works efficiently, it’s much easier to find restful sleep.
  • Prebiotic PreforPro®: This ingredient may relieve occasional stomach discomfort, as it stimulates beneficial bacteria growth in the gut.
  • Melatonin: This natural hormone works through the endocrine system, supporting the sleep/wake cycle of the circadian rhythm.
  • Herbs and Botanicals known for supporting sleep, such as lemon balm extract, chamomile or valerian root:

Probiotics in combination with botanical blends and other functional ingredients can promote healthy sleep, often making it more restorative.

Probiotics and Mood

Improving mood could start with the right probiotic supplement. Adding vitamins and amino acids in the formula encourages a normal, healthy mood. A good mood support with probiotics formula may consist of:

  • Bacillus subtilisDE111®: DE111 aids in the growth of good bacteria in the gut while out-competing undesirable bacteria for improved digestion. Some intestinal microbiota can secrete neurotransmitters. Increased amounts of good bacteria can have a positive impact on mood.
  • Bifidobacterium longum: This probiotic strain features in several studiesfocusing on the effects of probiotic supplementation on mood state. Those studies propose that probiotics may improve psychological well-being by ameliorating aspects of mood and sleep quality, reinforcing the theory of the gut-brain axis.
  • Solarplast®: This spinach extract contains photosynthetic complexes of energy molecules, vitamins and powerful antioxidants. They spark cellular energy production, which the body needs for all systems. The high antioxidant content may work to contest free radical damage, a cause of neuroinflammation. This can directly impact mood.
  • Additional vitamins and amino acids known to support a healthy mood, such as Vitamin D3 and L-theanine

Probiotics and the Immune System

A probiotic supplement with additional immune support ingredients can be very beneficial to the body. Probiotics already support gut health, which is critical to the immune system. A probiotic formula to support immune health could include:

  • Spore-forming probiotic bacteria with scientifically researched immune health benefits, such as B. subtilis DE111®, B. coagulans, and B. clausii
  • Solarplast®: This ingredient delivers detoxifying antioxidants, which can slow cell damage caused by free radicals. It contains glutathione and its enzyme partners that accelerate antioxidant reactions.
  • Immune health-supporting vitamins, minerals and immunostimulants like vitamin C, zinc, and beta glucan

Condition Specific Probiotic Formulas from Deerland

Deerland works with supplement brand marketers to develop these types of condition-specific probiotic formulas for sleep, mood and immune health. Learn more about our products today.

New Study: Prebiotic PreforPro® Shows Synbiotic Benefits for GI Function

Deerland Probiotics and Enzymes has announced the publication of a human clinical trial demonstrating the synbiotic benefits of PreforPro®, a unique and proprietary blend of bacteriophages, in promoting the balance of good bacteria in the microbiome.

The goal of the parallel-arm study was to investigate whether adding bacteriophages with a probiotic would provide additional benefits to gastrointestinal function as well as augment the microbiota in the gut compared to the probiotic by itself, suggesting a truly synergistic capability.

The study, “PHAGE-2 Study: Supplemental Bacteriophages Extend Bifidobacterium animalis subsp. lactis BL04 Benefits on Gut Health and Microbiota”, published in Nutrients, was a randomized, double-blind, placebo-controlled clinical intervention trial. In this study, 66 participants were randomly assigned to one of three groups: placebo; Bifidobacterium animalis BL04 (B. lactis BL04) 1 billion CFU; or B. lactis BL04 (1 billion CFU) plus PreforPro (15mg). Participants consumed one capsule per day for four weeks. The outcomes sought were impacts on GI discomfort as well as changes or modulation of the gut microbiota.

Overall, the researchers found that the individuals in the B. lactis plus PreforPro group showed the following:

  • Improvements in self-reported GI inflammation symptoms
  • Reduction in colonic cramp discomfort
  • Greater increase in the presence of Lactobacillus vs. placebo
  • Decrease of strains Citrobacter and Desulfovibrio, which are associated with gut inflammation and GI disorders
  • Reduction in E. coli

In conclusion, the study demonstrates that supplementing B. lactis BL04 with PreforPro can significantly modulate gut ecology to favor beneficial bacteria. “In addition, a lack of global changes to the microbiota (dysbiosis) in combination with specific modulation of certain taxa, like Lactobacillus, suggests that PreforPro displays prebiotic-like effects and may extend the GI benefits of consuming B. lactis or other probiotics.,” says John Deaton, vice president of science and technology for Deerland Probiotics & Enzymes.

“This study demonstrates the opportunity and capability of phages in the robust support of healthy microflora balance and the associated physiological benefits. Phages are clearly up-and-coming supplements in the rapidly burgeoning arena of microbiome support.”

Join Deerland at Petfood Forum Connect

Virtually visit Deerland Probiotics & Enzymes at our digital showroom at the 2020 Petfood Forum Connect!

In our digital showroom, you can learn more our microbiome health solutions, watch videos on how our probiotics, prebiotics and enzymes work, and speak directly with our staff for further discussion and questions. We look forward to meeting with you to learn more about your formulation needs and discuss how we can collaborate to add functional value to your pet applications.


Finding The Balance Between Gut Health and Stress, Energy Levels, Mood and Sleep

As the COVID-19 pandemic continues to impact society, concern for overall health has become a priority in addition to general immune support and other more targeted goals.

This broader approach to health will likely persist well into the new normal and beyond, with support for stress relief, mood, restful sleep, brain function, eye health and gut health set to play a lasting role in healthier habits.

With that in mind, Deerland has crafted a variety of condition-specific solutions aimed at translating a healthier gut into better overall health and well-being.

The Link Between Gut Health and Overall Well-Being

The neural, endocrine and immune systems form what’s known as the “gut-brain axis,” a pathway that allows for communication between the brain and gut and for a link that intertwines the health of the two.

A study published in “frontiers in Psychiatry” explored this connection and how  modifying a person’s microbial environment could elevate overall health, reporting that “overall, probiotics intake was noted to exert a positive effect on depressive mood state and sleep quality.”

In fact, the “exploratory study [showed] an improvement across time in different aspect of the profile of mood state, like sad mood, anger and fatigue only in healthy individuals which took probiotics.”

Put simply, adding probiotics to the routine of healthy individuals helped elevate their mood and promote quality sleep, which positively impacts stress and energy levels and more.

How Probiotics and Gut Health Elevate Overall Health and Mood

Probiotics exhibit many beneficial effects in those who utilize them, including:

– Strengthening and reinforcing the body’s immune system

– Aiding in digestion

– Helping ease commons issues like diarrhea and bloating

However, this new link between probiotics and gut health and mental well-being and mood is also producing promising effects.

In general, research shows that gastrointestinal irritation might signal the central nervous system to alter mood. It follows, then, that encouraging healthy gut changes using probiotics could lead to similar mood alterations, but for the better.

This could play a critical role in the health of a large segment of society, as research indicates that up to 30-40% of the population experiences some form of functional bowel problem.

While there’s still more to learn about the intricacies of the gut-brain axis, probiotics seem to have a key role to play in the future of both overall health and treatment of sleep and mood disorders.

How Deerland Supports this Journey toward Better Sleep, Mood and Energy

Deerland takes pride in crafting a variety of innovative probiotic solutions developed by our Ph.D.-led research and development team.

DE111, our clinically studied strain of Bacillus subtilis, delivers digestive and immune health benefits in the form of supplements, foods and beverages, providing an easy pathway toward caring for gut health and overall well-being.

To learn more about how Deerland helps deliver the benefits of good gut health visit https://www.deerland.com.

Renewed Healthy Habits Mindset Pushes Supplement Growth

The impact of the current health crisis is reaching every corner of the health-conscious market. U.S. consumers are looking for traditional and non-traditional ways to boost health, with desires encompassing both immunity support and products for other condition-specific concerns.

This renewed interest in healthy habits, coupled with high-stress levels, is causing significant growth in the supplement industry.

How Health-Conscious Are U.S. Consumers Today?

The drive to be healthy includes multiple factors. It’s not just what you eat or if you exercise regularly. Often, those consumers that are the most health-conscious add supplements to the mix.

The Council for Responsible Nutrition (CRN) reported that 77% of U.S. adults take a supplement, per its 2019 survey. This number could easily be trending up based on market forecasts from the Nutrition Business Journal.

NBJ released new data on sales and growth of specific segments, including supplements that target stress, mood and sleep. This growth also applies to support for brain, eye, and gut health.

It’s not a surprise to see consumers seeking dietary supplements during the height of the COVID-19 pandemic. It may provide them greater peace of mind in protecting their health. This new cognizance of the supplement market will likely be long-lasting, especially if consumers see results.

Probiotics: A Supplement That Supports Gut Health and More

One of the most popular supplements for consumers is probiotics. The growth of this market portion has been consistent, with a Research and Markets Report stating an expected 6% growth from 2019 to 2025. This same report also notes a possible strong surge throughout 2020.

Consumers can easily find supplements on eCommerce sites. They aren’t limited to a typical brick-and-mortar transaction, so retail disruption should have little impact on accessibility.

What many individuals find attractive about probiotics is their ability to support several areas. Their first job is to improve gut health, but because of the effects of gut health on the whole body, they can also be of use for stress, mood and sleep challenges.

Specially formulated probiotics answer this call and provide a more personalized approach to supplements. It’s not only a probiotic, but it includes ingredients to help with other concerns, including:

• Healthy skin
• Sleep support
• Women’s health
• Immune support
• Mood normalizers

Consumers likely have multiple supplement needs. If it’s possible to address those with one dose, it offers them convenience.

These buyers are also knowledgeable of the connection between gut health and immunity. It’s true that 70% of the body’s immune cells are in the digestive tract. As consumers pursue new remedies for building immunity, they’ll continue to stock up on probiotics.

Meeting Consumer Demand

Supplements, especially probiotics, are attractive to consumers in the current environment. How will you meet the demand? Having a broad selection of condition-specific formulations incorporating probiotics will be critical.

New Study: Enzyme Blend ProHydrolase® Potentiates Amino Acid Uptake

A newly published study adds to the portfolio of research demonstrating ProHydolase®, a proprietary protease enzyme blend from Deerland Probiotics & Enzymes, enhances the benefit of whey protein when taken together.

Deerland Probiotics and Enzymes has announced the publication of a clinical study demonstrating the effects of ProHydrolase® added to whey protein on post-resistance exercise aminoacidemia (very high uptake of amino acids in the blood).

To be effective, whey (and other) protein must be cleaved into smaller particle sizes within approximately 90 minutes after ingestion, from the time it arrives at the small intestine, the location where it is digested and absorbed. After absorption, the amino acids are utilized by the muscles for building and repair. This study underscores the need to support the body’s ability to break down the peptides in whey protein into smaller particle sizes for improved digestion and absorption. This is especially beneficial for athletes, trainers or other fitness enthusiasts who consume whey protein powders daily for muscle gain and strength.

The study, “The Effect of ProHydrolase® on the Amino Acid and Intramuscular Anabolic Signaling Response to Resistance Exercise in Trained Males”, published in Sports, is a randomized, double-blind, placebo-controlled study involving resistance-trained males. Participants completed four sets of 8–10 repetitions on the leg press and leg extension exercises, after which they consumed either 26g of whey protein alone, 26g of whey protein plus 250mg of ProHydrolase, or placebo.

Results showed that compared to immediately after consumption (0 minutes), those in the ProHydrolase+whey group demonstrated significantly elevated plasma leucine levels (33% increase) at 30 minutes.

These data corroborate previous research on ProHydrolase and amino acid concentrations where levels of leucine in the blood increased by 5% after 4 hours. Leucine availability has widespread relevance to supporting long-term human health. Leucine is the branch-chain amino acids (BCAA) which is the trigger for muscle synthesis that supports growth and repair of skeletal muscle, skin, and bones. It also supports regulation of blood-sugar levels and is a potentiator to Human Growth Hormone.

Additionally, the new study also showed that at 30 minutes post-consumption the ProHydrolase+whey group experienced a significant increase in BCAA plasma levels compared to those in the whey protein alone group — a difference of 33% for leucine, 32% for all BCAAs and 29% for essential amino acids. These remained elevated at 180 minutes post-ingestion.

“ProHydrolase is like protein powder’s perfect partner,” said Dr. John Deaton, vice president of science and technology at Deerland Probiotics & Enzymes. “The enzyme blend potentiates the powder’s ability to protect and improve muscle structure, especially after vigorous workouts. Without ProHydolase, whey or other protein powders may not be optimally used by the body.”

This study supports earlier clinical research showing that a dose of 10mg of ProHydrolase® per gram of whey protein isolate increased total amino acids in the blood (by 20%), as well as in vitro data showing that after 90 minutes, ProHydrolase increases the bioavailability of whey protein amino acids.

Deaton concluded, “More people are becoming active and using protein powders, whey or plant-based, in the singular attempt to feed their muscles. ProHydrolase is, without a doubt, a potent and perfect protein partner.”

Why Probiotic Gummies Should Join Your Product Line-Up

Probiotics are top-of-mind in today’s modern health landscape and are an essential way for people to maintain and improve digestive health. However, many consumers struggle with “pill fatigue” or prefer chewable over traditional supplements. In fact, adult gummies, are one of the fastest-growing segments in the vitamin market these days. By introducing probiotics into the gummy delivery system, manufacturers can meet this demand with a delicious and efficacious new way.