New Study: Prebiotic PreforPro® Shows Synbiotic Benefits for GI Function

Deerland Probiotics and Enzymes has announced the publication of a human clinical trial demonstrating the synbiotic benefits of PreforPro®, a unique and proprietary blend of bacteriophages, in promoting the balance of good bacteria in the microbiome.

The goal of the parallel-arm study was to investigate whether adding bacteriophages with a probiotic would provide additional benefits to gastrointestinal function as well as augment the microbiota in the gut compared to the probiotic by itself, suggesting a truly synergistic capability.

The study, “PHAGE-2 Study: Supplemental Bacteriophages Extend Bifidobacterium animalis subsp. lactis BL04 Benefits on Gut Health and Microbiota”, published in Nutrients, was a randomized, double-blind, placebo-controlled clinical intervention trial. In this study, 66 participants were randomly assigned to one of three groups: placebo; Bifidobacterium animalis BL04 (B. lactis BL04) 1 billion CFU; or B. lactis BL04 (1 billion CFU) plus PreforPro (15mg). Participants consumed one capsule per day for four weeks. The outcomes sought were impacts on GI discomfort as well as changes or modulation of the gut microbiota.

Overall, the researchers found that the individuals in the B. lactis plus PreforPro group showed the following:

  • Improvements in self-reported GI inflammation symptoms
  • Reduction in colonic cramp discomfort
  • Greater increase in the presence of Lactobacillus vs. placebo
  • Decrease of strains Citrobacter and Desulfovibrio, which are associated with gut inflammation and GI disorders
  • Reduction in E. coli

In conclusion, the study demonstrates that supplementing B. lactis BL04 with PreforPro can significantly modulate gut ecology to favor beneficial bacteria. “In addition, a lack of global changes to the microbiota (dysbiosis) in combination with specific modulation of certain taxa, like Lactobacillus, suggests that PreforPro displays prebiotic-like effects and may extend the GI benefits of consuming B. lactis or other probiotics.,” says John Deaton, vice president of science and technology for Deerland Probiotics & Enzymes.

“This study demonstrates the opportunity and capability of phages in the robust support of healthy microflora balance and the associated physiological benefits. Phages are clearly up-and-coming supplements in the rapidly burgeoning arena of microbiome support.”

New Study: Prebiotic PreforPro® Shows Synbiotic Benefits for GI Function

Deerland Probiotics and Enzymes has announced the publication of a human clinical trial demonstrating the synbiotic benefits of PreforPro®, a unique and proprietary blend of bacteriophages, in promoting the balance of good bacteria in the microbiome.

The goal of the parallel-arm study was to investigate whether adding bacteriophages with a probiotic would provide additional benefits to gastrointestinal function as well as augment the microbiota in the gut compared to the probiotic by itself, suggesting a truly synergistic capability.

The study, “PHAGE-2 Study: Supplemental Bacteriophages Extend Bifidobacterium animalis subsp. lactis BL04 Benefits on Gut Health and Microbiota”, published in Nutrients, was a randomized, double-blind, placebo-controlled clinical intervention trial. In this study, 66 participants were randomly assigned to one of three groups: placebo; Bifidobacterium animalis BL04 (B. lactis BL04) 1 billion CFU; or B. lactis BL04 (1 billion CFU) plus PreforPro (15mg). Participants consumed one capsule per day for four weeks. The outcomes sought were impacts on GI discomfort as well as changes or modulation of the gut microbiota.

Overall, the researchers found that the individuals in the B. lactis plus PreforPro group showed the following:

  • Improvements in self-reported GI inflammation symptoms
  • Reduction in colonic cramp discomfort
  • Greater increase in the presence of Lactobacillus vs. placebo
  • Decrease of strains Citrobacter and Desulfovibrio, which are associated with gut inflammation and GI disorders
  • Reduction in E. coli

In conclusion, the study demonstrates that supplementing B. lactis BL04 with PreforPro can significantly modulate gut ecology to favor beneficial bacteria. “In addition, a lack of global changes to the microbiota (dysbiosis) in combination with specific modulation of certain taxa, like Lactobacillus, suggests that PreforPro displays prebiotic-like effects and may extend the GI benefits of consuming B. lactis or other probiotics.,” says John Deaton, vice president of science and technology for Deerland Probiotics & Enzymes.

“This study demonstrates the opportunity and capability of phages in the robust support of healthy microflora balance and the associated physiological benefits. Phages are clearly up-and-coming supplements in the rapidly burgeoning arena of microbiome support.”

Join Deerland at Petfood Forum Connect

Virtually visit Deerland Probiotics & Enzymes at our digital showroom at the 2020 Petfood Forum Connect!

In our digital showroom, you can learn more our microbiome health solutions, watch videos on how our probiotics, prebiotics and enzymes work, and speak directly with our staff for further discussion and questions. We look forward to meeting with you to learn more about your formulation needs and discuss how we can collaborate to add functional value to your pet applications.

VISIT OUR DIGITAL SHOWROOM

Deerland Announces Family First™ Platform, Kicks Off With Virtual Summit Event

With all its uncertainty and adversity, 2020 has also ushered in a renewed sense of “togetherness” as citizens of the world rediscover the importance of family and the health and wellness of every member of the household.

To support this heightened focus on the family, Deerland is launching the “Family First” platform, a series of content that will help product marketers connect consumers with the science-supported health product solutions they seek.

First up is an industry-wide virtual summit focusing on children’s microbiome and whole-family immune health.

Titled “Family First: Addressing consumer demand for whole-family health solutions starts with the microbiome,” this event will provide a platform for Deerland, Informa Health & Nutrition and leading industry experts to dig into the latest science, insights and research influencing how the supplement industry develops innovative, research-backed solutions for today’s consumers.

When: August 19, Noon to 3 p.m. EDT

  • Keynote: Dr. Robynne Chutkan, “Breakthroughs in whole-body, whole-family health”
  • Eric Pierce, Vice President Business Insights, Informa Health & Nutrition: Probiotic Market Analysis
  • Dr. John Deaton, Vice President Science and Technology, Deerland: “Scientific breakthroughs in probiotics”

Audience polling, breakout discussions and networking opportunities will also help elevate this tremendous virtual opportunity.

To register, visit https://www.naturalproductsinsider.com/probiotics-prebiotics/family-first-virtual-summit.

Deerland Probiotics & Enzymes Positioned to Collaborate with Customers Worldwide

Customers Now Have Full Access to an Expanded Portfolio of Science-Backed Probiotic, Prebiotic and Enzyme Technologies

Deerland Probiotics & Enzymes (“Deerland”), a global supplier of science-backed solutions for microbiome health, announced today that it has completed the integration of Denmark-based Bifodan A/S which was acquired in 2019. The two companies now operate as one global entity under the Deerland brand.

With this development, customers of Deerland and the former Bifodan now enjoy full access to an expanded portfolio of science-backed probiotic, prebiotic and enzyme technologies through branded ingredients, customized formulations, and ready-to-market turnkey solutions in more than 40 countries around the world.

“We are excited to unleash the power of two organizations, now operating as one elite global solutions provider,” said Scott Ravech, CEO of Deerland. “Together, we are one step closer to achieving our vision of all people of all cultures benefiting from our enzyme, probiotic and prebiotic health products and science-backed technologies.”

Deerland’s acquisition of Bifodan effectively enlarged its global footprint making the company’s value proposition stronger than ever. In the months following the acquisition, the companies worked together to integrate the two organizations to better serve their existing and new customers. Sales and marketing teams addressed how the combined company would collaborate with customers to develop innovative and proprietary solutions. The global research and development teams ensured each product offering would be supported with sound clinical science, and manufacturing teams optimized production in the company’s four state-of-the-art TGA and cGMP certified facilities around the globe.

New Study: Enzyme Blend ProHydrolase® Potentiates Amino Acid Uptake

A newly published study adds to the portfolio of research demonstrating ProHydolase®, a proprietary protease enzyme blend from Deerland Probiotics & Enzymes, enhances the benefit of whey protein when taken together.

Deerland Probiotics and Enzymes has announced the publication of a clinical study demonstrating the effects of ProHydrolase® added to whey protein on post-resistance exercise aminoacidemia (very high uptake of amino acids in the blood).

To be effective, whey (and other) protein must be cleaved into smaller particle sizes within approximately 90 minutes after ingestion, from the time it arrives at the small intestine, the location where it is digested and absorbed. After absorption, the amino acids are utilized by the muscles for building and repair. This study underscores the need to support the body’s ability to break down the peptides in whey protein into smaller particle sizes for improved digestion and absorption. This is especially beneficial for athletes, trainers or other fitness enthusiasts who consume whey protein powders daily for muscle gain and strength.

The study, “The Effect of ProHydrolase® on the Amino Acid and Intramuscular Anabolic Signaling Response to Resistance Exercise in Trained Males”, published in Sports, is a randomized, double-blind, placebo-controlled study involving resistance-trained males. Participants completed four sets of 8–10 repetitions on the leg press and leg extension exercises, after which they consumed either 26g of whey protein alone, 26g of whey protein plus 250mg of ProHydrolase, or placebo.

Results showed that compared to immediately after consumption (0 minutes), those in the ProHydrolase+whey group demonstrated significantly elevated plasma leucine levels (33% increase) at 30 minutes.

These data corroborate previous research on ProHydrolase and amino acid concentrations where levels of leucine in the blood increased by 5% after 4 hours. Leucine availability has widespread relevance to supporting long-term human health. Leucine is the branch-chain amino acids (BCAA) which is the trigger for muscle synthesis that supports growth and repair of skeletal muscle, skin, and bones. It also supports regulation of blood-sugar levels and is a potentiator to Human Growth Hormone.

Additionally, the new study also showed that at 30 minutes post-consumption the ProHydrolase+whey group experienced a significant increase in BCAA plasma levels compared to those in the whey protein alone group — a difference of 33% for leucine, 32% for all BCAAs and 29% for essential amino acids. These remained elevated at 180 minutes post-ingestion.

“ProHydrolase is like protein powder’s perfect partner,” said Dr. John Deaton, vice president of science and technology at Deerland Probiotics & Enzymes. “The enzyme blend potentiates the powder’s ability to protect and improve muscle structure, especially after vigorous workouts. Without ProHydolase, whey or other protein powders may not be optimally used by the body.”

This study supports earlier clinical research showing that a dose of 10mg of ProHydrolase® per gram of whey protein isolate increased total amino acids in the blood (by 20%), as well as in vitro data showing that after 90 minutes, ProHydrolase increases the bioavailability of whey protein amino acids.

Deaton concluded, “More people are becoming active and using protein powders, whey or plant-based, in the singular attempt to feed their muscles. ProHydrolase is, without a doubt, a potent and perfect protein partner.”

COVID-19 Update: Deerland Classified as an Essential Business

Deerland is a USA-based business with manufacturing facilities in Kennesaw, Georgia and Forsyth, Missouri. The governors of Georgia and Missouri have yet to announce official stay-at-home orders for their entire states. However, many local city and county leaders are taking actions to implement stay-at-home orders, which include the shut-down or limited hours of all nonessential businesses. Under these types of orders, Deerland is considered an essential business and will remain open in all locations.
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Latest Updates Regarding COVID-19

As the situation with the novel coronavirus COVID-19 continues to evolve, I want to give you an update on the measures being taken at Deerland to prioritize the health and safety of our employees as well as mitigate the risk of disruption to our business and yours.

As always, our employees are expected to adhere to the safety and standard operating procedures we have in place across our facilities. In our manufacturing areas, this includes our standard practice of donning personal protective equipment (PPE) that includes (by production function) the use of full body Tyvek suits, respirators, facial masks, gloves, gowns, and safety glasses. Great care is always taken by employees to ensure full compliance with all our hygiene and safety protocols.

Precautions are now being taken to mitigate the risk of COVID-19 transmission in our workplace and to ensure the continued safe manufacture of products, including:

Internal

  • Reinforcing hygiene guidelines outlined by the world health experts, including the CDC, urging employees to limit close interaction with others when in public places
  • Additional hand sanitization stations and increased frequency of surface wipe-downs with sanitizing solutions throughout our facilities and in all meeting areas
  • Strict adherence to our policy of staying home if ill and to immediately seeking medical care as necessary
  • Requirement for employees to notify leadership of the commencement and return of private travel
  • Implementing additional cross-training initiatives to address any workforce impact thereby minimizing business disruption

External

  • Implementing a forward purchasing plan to pre-buy all applicable raw materials and applicable PPE; suppliers are also expected to also have adequate safety stock levels in their warehouses
  • Suppliers have been asked to immediately provide their business disruption avoidance plans to ensure continuity of supply. Additionally, they are expected to provide timely updates as they become available.

Please trust we are taking the threat of the novel coronavirus very seriously and will continue to do everything we can to minimize any supply disruption.

As always, we appreciate our business relationship with you and will continue to provide any applicable updates as warranted.

If you have any questions, please do not hesitate to contact your Deerland Business Development Manager or Customer Service Representative.

-Scott Ravech, CEO

Deerland Probiotics & Enzymes Achieves Certification from Australia’s Therapeutic Goods Administration (TGA)

Globally Recognized Quality Certification Puts Deerland in Elite Class of Manufacturers

Deerland Probiotics & Enzymes, supplier of science-backed solutions for microbiome health, is pleased to announce that it is expanding its list of Good Manufacturing Practice (GMP) certifications with the addition of Australia’s Therapeutic Goods Administration (TGA) Certification at its Kennesaw, Georgia facilities. TGA certification represents that Deerland has demonstrated GMP management practices and systems in compliance with the manufacturing standards established by the Australian Government Department of Health and Ageing. With this most recent certification in Kennesaw and the existing certification renewal at the company’s Forsyth, MO facility, all of Deerland’s facilities have earned the elite status. In addition, the Denmark-based facility of Bifodan A/S, recently acquired by Deerland, has a mutual recognition agreement with Australia enabling it to produce TGA-certified products as well.

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Deerland Probiotics & Enzymes Announces Acquisition of Bifodan A/S

Acquisition Gives Deerland a Larger Global Footprint

Deerland Probiotics & Enzymes, a US-based supplier of science-backed solutions for microbiome health, announced today its acquisition of Bifodan A/S. Bifodan, based in Hundested, Denmark, is a life science company specialized in developing, manufacturing and distributing unique probiotic product solutions as private label dietary supplements, medical devices and OTC drugs.

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Deerland Earns Non-GMO Project Verification for Solarplast® Antioxidant Ingredient

Deerland is pleased to announce that it has earned Non-GMO Project verification for Solarplast®, the company’s branded enzyme-powered antioxidant ingredient for healthy aging and beauty from within.

Solarplast is the most recent of Deerland’s portfolio of branded products to earn the verification. “Consumer demand for non-GMO supplements is on the rise, and Deerland is responding in order to provide added value for our customers,” said Sam Michini, vice president of marketing and strategy at Deerland. “We’re pleased to work with the Non-GMO Project, the leading verifier of non-GMO products in the United States.”

Solarplast provides a host of benefits for healthy aging, optimizing the body’s processes through cellular restoration and repair. An innovative and totally unique process breaks down the cell wall of organic spinach – something the body struggles to do– while still preserving the integrity of the plant’s protoplast, the most nutrient dense compartment. “Solarplast provides massive natural concentrations of detoxifying antioxidants that slow the natural process of cell damage that comes from free radicals–and this antioxidant power is exponentially greater due to the presence of enzymes that facilitate the glutathione pathway of antioxidant regeneration,” explains Dr. John Deaton, vice president of science and technology.

Solarplast is an ideal ingredient technology for products geared toward healthy aging and beauty from within. The organic green powder can be delivered through traditional supplement capsules, powder blends such as protein or smoothie mixes, as well as finished food and beverage products.

Attendees of SupplySide West in October are invited to visit the Deerland booth #4524 to learn more about Solarplast and the science behind it. Deerland’s experts will be on hand to discuss product formulation ideas.

Deerland Probiotics & Enzymes, based in Kennesaw, Ga., specializes in developing science-backed solutions that benefit microbiome health, using probiotic, prebiotic and enzyme technology. The company offers a line of unique, clinically supported branded products, including DE111®, PreforPro®, ProHydrolase®, Solarplast® and Glutalytic®. Deerland collaborates with customers to develop innovative and often proprietary solutions in the dietary supplement and food and beverage markets. In addition to branded ingredients and customized formulations, Deerland offers full turn key manufacturing services, including bulk blends, capsules, stick packs and tablets; as well as bottling and labeling. To contact Deerland Probiotics & Enzymes, call 800.697.8179 or visit www.deerland.com.

Deerland Receives GRAS No-Objection Letter from FDA for Probiotic DE111®

Deerland is proud to announce that the FDA has issued a GRAS (Generally Recognized As Safe) No Objection Letter for its branded probiotic strain, Bacillus subtilis DE111®. A “Letter of No Objection” refers to the letter sent by the FDA confirming that they do not question the basis for the GRAS self-affirmation notification established and submitted by Deerland.

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